C—H Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation

Ingenol derivatives with varying degrees of oxidation were prepared by two‐phase terpene synthesis. This strategy has allowed access to analogues that cannot be prepared by semisynthesis from natural ingenol. Complex ingenanes resulting from divergent C—H oxidation of a common intermediate were foun...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Jin, Yehua, Yeh, Chien‐Hung, Kuttruff, Christian A., Jørgensen, Lars, Dünstl, Georg, Felding, Jakob, Natarajan, Swaminathan R., Baran, Phil S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: WILEY‐VCH Verlag 2015
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832842/
https://ncbi.nlm.nih.gov/pubmed/26418078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507977
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