C—H Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation

Ingenol derivatives with varying degrees of oxidation were prepared by two‐phase terpene synthesis. This strategy has allowed access to analogues that cannot be prepared by semisynthesis from natural ingenol. Complex ingenanes resulting from divergent C—H oxidation of a common intermediate were foun...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Jin, Yehua, Yeh, Chien‐Hung, Kuttruff, Christian A., Jørgensen, Lars, Dünstl, Georg, Felding, Jakob, Natarajan, Swaminathan R., Baran, Phil S.
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY‐VCH Verlag 2015
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832842/
https://ncbi.nlm.nih.gov/pubmed/26418078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507977
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