Mutations in human tubulin proximal to the kinesin binding site alter dynamic instability at microtubule plus- and minus-ends

The assembly of microtubule-based cellular structures depends on regulated tubulin polymerization and directional transport. Here, we purify and characterize tubulin heterodimers that have human β-tubulin isotype III (TUBB3), and heterodimers with one of two β-tubulin mutations (D417H or R262H). Bot...

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Pubblicato in:Dev Cell
Autori principali: Ti, Shih-Chieh, Pamula, Melissa C., Howes, Stuart C., Duellberg, Christian, Cade, Nicholas I., Kleiner, Ralph E., Forth, Scott, Surrey, Thomas, Nogales, Eva, Kapoor, Tarun M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832424/
https://ncbi.nlm.nih.gov/pubmed/27046833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.03.003
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