Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy

Antidepressant drugs are too often ineffective, the exact mechanism of efficacy is still ambiguous, and there has been a paucity of novel targets for pharmacotherapy. In an attempt to understand the pathogenesis of depression and subsequently develop more efficacious antidepressant drugs, multiple t...

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Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Wainwright, Steven R, Barha, Cindy K, Hamson, Dwayne K, Epp, Jonathan R, Chow, Carmen, Lieblich, Stephanie E, Rutishauser, Urs, Galea, Liisa AM
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832030/
https://ncbi.nlm.nih.gov/pubmed/26530284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.337
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