Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy

Antidepressant drugs are too often ineffective, the exact mechanism of efficacy is still ambiguous, and there has been a paucity of novel targets for pharmacotherapy. In an attempt to understand the pathogenesis of depression and subsequently develop more efficacious antidepressant drugs, multiple t...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Wainwright, Steven R, Barha, Cindy K, Hamson, Dwayne K, Epp, Jonathan R, Chow, Carmen, Lieblich, Stephanie E, Rutishauser, Urs, Galea, Liisa AM
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832030/
https://ncbi.nlm.nih.gov/pubmed/26530284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.337
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