Enzymatic Engineering of Polysialic Acid on Cells in Vitro and in Vivo Using a Purified Bacterial Polysialyltransferase

In vertebrates, polysialic acid (PSA) is typically added to the neural cell adhesion molecule (NCAM) in the Golgi by PST or STX polysialyltransferase. PSA promotes plasticity, and its enhanced expression by viral delivery of the PST or STX gene has been shown to promote cellular processes that are u...

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Bibliographic Details
Main Authors: El Maarouf, Abderrahman, Moyo-Lee Yaw, Damali, Lindhout, Theresa, Pearse, Damien D., Wakarchuk, Warren, Rutishauser, Urs
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463313/
https://ncbi.nlm.nih.gov/pubmed/22851175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377614
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