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Structural and Functional Impairments of Polysialic Acid by a Mutated Polysialyltransferase Found in Schizophrenia

Polysialic acid (polySia), a unique acidic glycan modifying neural cell adhesion molecule (NCAM), is known to regulate embryonic neural development and adult brain functions. Polysialyltransferase STX is responsible for the synthesis of polySia, and two single nucleotide polymorphisms (SNPs) of the...

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Autori principali: Isomura, Ryo, Kitajima, Ken, Sato, Chihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122212/
https://ncbi.nlm.nih.gov/pubmed/21464126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221143
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