Neural Cell Adhesion Molecule and its Polysialic Acid Moiety Exhibit Opposing and Linked Effects on Neuropathic Hyperalgesia

Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropa...

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Hlavní autoři: El Maarouf, Abderrahman, Kolesnikov, Yuri, Pasternak, Gavril, Rutishauser, Urs
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041112/
https://ncbi.nlm.nih.gov/pubmed/22200540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.12.017
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