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Neural Cell Adhesion Molecule and its Polysialic Acid Moiety Exhibit Opposing and Linked Effects on Neuropathic Hyperalgesia
Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041112/ https://ncbi.nlm.nih.gov/pubmed/22200540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.12.017 |
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