Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors

How is information communicated both within and between cells of living systems with high signal to noise? We discuss transmembrane signaling models involving two receptor tyrosine kinases: the fibroblast growth factor receptor (FGFR) and the MET receptor. We suggest that simple dimerization models...

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Bibliografiske detaljer
Udgivet i:Prog Biophys Mol Biol
Main Authors: Blaszczyk, Michal, Harmer, Nicholas J., Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L.
Format: Artigo
Sprog:Inglês
Udgivet: Pergamon Press 2015
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832006/
https://ncbi.nlm.nih.gov/pubmed/25957048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2015.04.007
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