Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

Drug-induced liver injury (DILI) is an important problem both in the clinic and in the development of new safer medicines. Two pivotal adaptation and survival responses to adverse drug reactions are oxidative stress and cytokine signaling based on the activation of the transcription factors Nrf2 and...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, van de Water, Bob
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Organ Toxicity and Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830895/
https://ncbi.nlm.nih.gov/pubmed/26026609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1536-3
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