Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

Drug-induced liver injury (DILI) is an important problem both in the clinic and in the development of new safer medicines. Two pivotal adaptation and survival responses to adverse drug reactions are oxidative stress and cytokine signaling based on the activation of the transcription factors Nrf2 and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Toxicol
Prif Awduron: Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, van de Water, Bob
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2015
Pynciau:
Organ Toxicity and Mechanisms
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830895/
https://ncbi.nlm.nih.gov/pubmed/26026609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1536-3
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