Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

Drug-induced liver injury (DILI) is an important problem both in the clinic and in the development of new safer medicines. Two pivotal adaptation and survival responses to adverse drug reactions are oxidative stress and cytokine signaling based on the activation of the transcription factors Nrf2 and...

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Vydáno v:Arch Toxicol
Hlavní autoři: Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, van de Water, Bob
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2015
Témata:
Organ Toxicity and Mechanisms
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830895/
https://ncbi.nlm.nih.gov/pubmed/26026609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1536-3
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