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Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
Mutations in the human telomerase RNA (hTR), the telomerase RNP component dyskerin (DKC1), and the poly(A) ribonuclease (PARN) can lead to reduced levels of hTR and dyskeratosis congenita (DC). However, the enzymes and mechanisms responsible for hTR degradation are unknown. We demonstrate that defec...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4830462/ https://ncbi.nlm.nih.gov/pubmed/26950371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3184 |
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