Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model

OBJECTIVES: Clostridium difficile infection (CDI) is a primary cause of antibiotic-associated diarrhoeal illness. Current therapies are insufficient as relapse rates following antibiotic treatment range from 25% for initial treatment to 60% for treatment of recurrence. In this study, we looked at th...

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Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Moore, John H., van Opstal, Edward, Kolling, Glynis L., Shin, Jae Hyun, Bogatcheva, Elena, Nikonenko, Boris, Einck, Leo, Phipps, Andrew J., Guerrant, Richard L., Protopopova, Marina, Warren, Cirle Alcantara
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830414/
https://ncbi.nlm.nih.gov/pubmed/26832756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv479
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