Chemical modification of capuramycins to enhance antibacterial activity

OBJECTIVES: To extend capuramycin spectrum of activity beyond mycobacteria and improve intracellular drug activity. METHODS: Three capuramycin analogues (SQ997, SQ922 and SQ641) were conjugated with different natural and unnatural amino acids or decanoic acid (DEC) through an ester bond at one or mo...

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Bibliographic Details
Main Authors: Bogatcheva, Elena, Dubuisson, Tia, Protopopova, Marina, Einck, Leo, Nacy, Carol A., Reddy, Venkata M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037154/
https://ncbi.nlm.nih.gov/pubmed/21186194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq495
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