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Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

As traditional antidepressants act only after weeks/months, the discovery that ketamine, an antagonist of glutamate/NMDA receptors, elicits antidepressant actions in hours has been transformative. Its mechanism of action has been elusive, though enhanced mTOR signaling is a major feature. We report...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Harraz, Maged M., Tyagi, Richa, Cortés, Pedro, Snyder, Solomon H.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830355/
https://ncbi.nlm.nih.gov/pubmed/26782056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.211
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