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Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation
As traditional antidepressants act only after weeks/months, the discovery that ketamine, an antagonist of glutamate/NMDA receptors, elicits antidepressant actions in hours has been transformative. Its mechanism of action has been elusive, though enhanced mTOR signaling is a major feature. We report...
שמור ב:
| הוצא לאור ב: | Mol Psychiatry |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4830355/ https://ncbi.nlm.nih.gov/pubmed/26782056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.211 |
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