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Antidepressant Effects of AMPA and Ketamine Combination: Role of Hippocampal BDNF, Synapsin, and mTOR

RATIONALE: A number of preclinical and clinical studies suggest ketamine, a glutamate NMDA (N-methyl-D-aspartate) receptor antagonist, has a rapid and lasting antidepressant effect when administered either acutely or chronically. It has been postulated that this effect is due to stimulation of AMPA...

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Bibliographic Details
Main Authors: Akinfiresoye, Luli, Tizabi, Yousef
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805670/
https://ncbi.nlm.nih.gov/pubmed/23732839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-013-3153-2
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