Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes

Sézary Syndrome is a rare leukemic form of cutaneous T-cell lymphoma defined as erythroderma, adenopathy, and circulating atypical T-lymphocytes. It is rarely curable with poor prognosis. Here we present a multi-platform genomic analysis of 37 Sézary Syndrome patients that implicates dysregulation o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Genet
Prif Awduron: Wang, Linghua, Ni, Xiao, Covington, Kyle R., Yang, Betty Y., Shiu, Jessica, Zhang, Xiang, Xi, Liu, Meng, Qingchang, Langridge, Timothy, Drummond, Jennifer, Donehower, Lawrence A., Doddapaneni, Harshavardhan, Muzny, Donna M., Gibbs, Richard A., Wheeler, David A., Duvic, Madeleine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829974/
https://ncbi.nlm.nih.gov/pubmed/26551670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3444
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