Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes

Sézary Syndrome is a rare leukemic form of cutaneous T-cell lymphoma defined as erythroderma, adenopathy, and circulating atypical T-lymphocytes. It is rarely curable with poor prognosis. Here we present a multi-platform genomic analysis of 37 Sézary Syndrome patients that implicates dysregulation o...

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Vydáno v:Nat Genet
Hlavní autoři: Wang, Linghua, Ni, Xiao, Covington, Kyle R., Yang, Betty Y., Shiu, Jessica, Zhang, Xiang, Xi, Liu, Meng, Qingchang, Langridge, Timothy, Drummond, Jennifer, Donehower, Lawrence A., Doddapaneni, Harshavardhan, Muzny, Donna M., Gibbs, Richard A., Wheeler, David A., Duvic, Madeleine
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829974/
https://ncbi.nlm.nih.gov/pubmed/26551670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3444
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