Depletion of regulatory T cells by targeting CC chemokine receptor type 4 with mogamulizumab

The CC chemokine receptor 4 (CCR4) is highly expressed on type 2 helper T cells and regulatory T (Treg) cells. Mogamulizumab, an anti-CCR4 antibody, reduces the numbers of CCR4(+) malignant T cells and CCR4(+) Treg cells in cutaneous T-cell lymphoma. Depleting Treg cells by targeting CCR4 has great...

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Vydáno v:Oncoimmunology
Hlavní autoři: Ni, Xiao, Langridge, Timothy, Duvic, Madeleine
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485778/
https://ncbi.nlm.nih.gov/pubmed/26140234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1011524
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