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Depletion of regulatory T cells by targeting CC chemokine receptor type 4 with mogamulizumab
The CC chemokine receptor 4 (CCR4) is highly expressed on type 2 helper T cells and regulatory T (Treg) cells. Mogamulizumab, an anti-CCR4 antibody, reduces the numbers of CCR4(+) malignant T cells and CCR4(+) Treg cells in cutaneous T-cell lymphoma. Depleting Treg cells by targeting CCR4 has great...
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| Publicado no: | Oncoimmunology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485778/ https://ncbi.nlm.nih.gov/pubmed/26140234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1011524 |
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