Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

Th2 cells produce Th2 cytokines such as IL-4, IL-5 and IL-13, but repress Th1 cytokine IFNγ. Recent studies have revealed various distinct memory-type Th2 cell subsets, one of which produces a substantial amount of IFNγ in addition to Th2 cytokines, however it remains unclear precisely how these Th2...

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Udgivet i:Nat Commun
Main Authors: Hosokawa, Hiroyuki, Tanaka, Tomoaki, Endo, Yusuke, Kato, Miki, Shinoda, Kenta, Suzuki, Akane, Motohashi, Shinichiro, Matsumoto, Masaki, Nakayama, Keiichi I., Nakayama, Toshinori
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829694/
https://ncbi.nlm.nih.gov/pubmed/27053161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11289
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