Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression

GATA-binding protein 3 (Gata3) controls the differentiation of naive CD4 T cells into T helper 2 (Th2) cells by induction of chromatin remodeling of the Th2 cytokine gene loci, direct transactivation of Il5 and Il13 genes, and inhibition of Ifng. Gata3 also facilitates Th2 cell proliferation via add...

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Autori principali: Hosokawa, Hiroyuki, Tanaka, Tomoaki, Kato, Miki, Shinoda, Kenta, Tohyama, Hiroyuki, Hanazawa, Asami, Tamaki, Yuuki, Hirahara, Kiyoshi, Yagi, Ryoji, Sakikawa, Ikue, Morita, Atsushi, Nagira, Morio, Poyurovsky, Masha V., Suzuki, Yutaka, Motohashi, Shinichiro, Nakayama, Toshinori
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832009/
https://ncbi.nlm.nih.gov/pubmed/24167278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311100110
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