Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression

GATA-binding protein 3 (Gata3) controls the differentiation of naive CD4 T cells into T helper 2 (Th2) cells by induction of chromatin remodeling of the Th2 cytokine gene loci, direct transactivation of Il5 and Il13 genes, and inhibition of Ifng. Gata3 also facilitates Th2 cell proliferation via add...

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Main Authors: Hosokawa, Hiroyuki, Tanaka, Tomoaki, Kato, Miki, Shinoda, Kenta, Tohyama, Hiroyuki, Hanazawa, Asami, Tamaki, Yuuki, Hirahara, Kiyoshi, Yagi, Ryoji, Sakikawa, Ikue, Morita, Atsushi, Nagira, Morio, Poyurovsky, Masha V., Suzuki, Yutaka, Motohashi, Shinichiro, Nakayama, Toshinori
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832009/
https://ncbi.nlm.nih.gov/pubmed/24167278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311100110
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