N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to tr...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Lee, John K., Phillips, John W., Smith, Bryan A., Park, Jung Wook, Stoyanova, Tanya, McCaffrey, Erin F., Baertsch, Robert, Sokolov, Artem, Meyerowitz, Justin G., Mathis, Colleen, Cheng, Donghui, Stuart, Joshua M., Shokat, Kevan M., Gustafson, W. Clay, Huang, Jiaoti, Witte, Owen N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829466/
https://ncbi.nlm.nih.gov/pubmed/27050099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.03.001
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