N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to tr...

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Publicat a:Cancer Cell
Autors principals: Lee, John K., Phillips, John W., Smith, Bryan A., Park, Jung Wook, Stoyanova, Tanya, McCaffrey, Erin F., Baertsch, Robert, Sokolov, Artem, Meyerowitz, Justin G., Mathis, Colleen, Cheng, Donghui, Stuart, Joshua M., Shokat, Kevan M., Gustafson, W. Clay, Huang, Jiaoti, Witte, Owen N.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829466/
https://ncbi.nlm.nih.gov/pubmed/27050099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.03.001
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