Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

The aim of this study was to investigate the role of macrophage polarization in aging heart. Macrophage differentiation is pathogenically linked to many inflammatory and immune disorders. It is often preceded by myocardial inflammation, which is characterized by increased cardiac damage and pro-infl...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Karuppagounder, Vengadeshprabhu, Giridharan, Vijayasree V., Arumugam, Somasundaram, Sreedhar, Remya, Palaniyandi, Suresh S., Krishnamurthy, Prasanna, Quevedo, Joao, Watanabe, Kenichi, Konishi, Tetsuya, Thandavarayan, Rajarajan A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829159/
https://ncbi.nlm.nih.gov/pubmed/27070323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152922
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