Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

Amyloid β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Our previous studies have demonstrated that schisandrin B (Sch B), an antioxidant lignan from Schisandra chinensis, could protect mouse brain against scopolamine- and cisplatin-induced neuronal dysfun...

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Udgivet i:PLoS One
Main Authors: Giridharan, Vijayasree V., Thandavarayan, Rajarajan A., Arumugam, Somasundaram, Mizuno, Makoto, Nawa, Hiroyuki, Suzuki, Kenji, Ko, Kam M., Krishnamurthy, Prasanna, Watanabe, Kenichi, Konishi, Tetsuya
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640572/
https://ncbi.nlm.nih.gov/pubmed/26556721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142483
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