Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

Doxorubicin (Dox) is a highly effective antineoplastic drug. However, Dox-induced apoptosis in cardiomyocytes leads to irreversible degenerative cardiomyopathy, which limits Dox clinical application. Schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Thandavarayan, Rajarajan A., Giridharan, Vijayasree V., Arumugam, Somasundaram, Suzuki, Kenji, Ko, Kam Ming, Krishnamurthy, Prasanna, Watanabe, Kenichi, Konishi, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351084/
https://ncbi.nlm.nih.gov/pubmed/25742619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119214
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