Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling

Angiosarcoma/lymphangiosarcoma is a rare malignancy with poor prognosis. We generated a mouse model with inducible endothelial cell-specific deletion of Tsc1 to examine mTORC1 signaling in lymphangiosarcoma. Tsc1 loss increased retinal angiogenesis in neonates, and led to endothelial proliferative l...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Sun, Shaogang, Chen, Song, Liu, Fei, Wu, Haige, McHugh, Jonathan, Bergin, Ingrid L., Gupta, Anita, Adams, Denise, Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828306/
https://ncbi.nlm.nih.gov/pubmed/26777415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.10.004
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