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Structural Interrogation of Benzosuberene-Based Inhibitors of Tubulin Polymerization
The discovery of 3-methoxy-9-(3′,4′,5′-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol (a benzosuberene-based analogue referred to as KGP18) was originally inspired by the natural products colchicine and combretastatin A-4 (CA4). The relative structural simplicity and ease of synthesis of KGP1...
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Publicado no: | Bioorg Med Chem |
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Main Authors: | , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4828293/ https://ncbi.nlm.nih.gov/pubmed/26775540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.10.012 |
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