Structural Interrogation of Benzosuberene-Based Inhibitors of Tubulin Polymerization

The discovery of 3-methoxy-9-(3′,4′,5′-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol (a benzosuberene-based analogue referred to as KGP18) was originally inspired by the natural products colchicine and combretastatin A-4 (CA4). The relative structural simplicity and ease of synthesis of KGP1...

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Publicado en:Bioorg Med Chem
Main Authors: Herdman, Christine A., Devkota, Laxman, Lin, Chen-Ming, Niu, Haichan, Strecker, Tracy E., Lopez, Ramona, Liu, Li, George, Clinton S., Tanpure, Rajendra P., Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828293/
https://ncbi.nlm.nih.gov/pubmed/26775540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.10.012
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