Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice

BACKGROUND: Ethanol feeding in mice activates complement via C1q binding to apoptotic cells in the liver; complement contributes to ethanol-induced inflammation and injury. Despite the critical role of C1q in ethanol-induced injury, the mechanism by which ethanol activates C1q remains poorly underst...

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Publicado en:Mol Immunol
Autores principales: Smathers, Rebecca L., Chiang, Dian J., McMullen, Megan R., Feldstein, Ariel E., Roychowdhury, Sanjoy, Nagy, Laura E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828291/
https://ncbi.nlm.nih.gov/pubmed/26922040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2016.02.008
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