Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl(4)-induced fibrosis but not steatosis or inflammation

BACKGROUND: Correlative evidence indicates that apoptosis is associated with the progression of alcoholic liver disease. If apoptosis contributes to ethanol-induced steatohepatitis and/or fibrosis, then mice deficient in Bid, a key pro-apoptotic Bcl-2 family member, or mice treated with a pan-caspas...

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Библиографические подробности
Главные авторы: Roychowdhury, Sanjoy, Chiang, Dian J., Mandal, Palash, McMullen, Megan R., Liu, Xiuli, Cohen, Jessica I., Pollard, John, Feldstein, Ariel E., Nagy, Laura E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337974/
https://ncbi.nlm.nih.gov/pubmed/22273278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2011.01720.x
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