Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Current astrocytoma models are limited in their ability to define the roles of oncogenic mutations in specific brain cell types during disease pathogenesis and their utility for preclinical drug development. In order to design a better model system for these applications, phenotypically wild-type co...

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Publicat a:J Vis Exp
Autors principals: McNeill, Robert S., Schmid, Ralf S., Bash, Ryan E., Vitucci, Mark, White, Kristen K., Werneke, Andrea M., Constance, Brian H., Huff, Byron, Miller, C. Ryan
Format: Artigo
Idioma:Inglês
Publicat: MyJove Corporation 2014
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827968/
https://ncbi.nlm.nih.gov/pubmed/25146643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/51763
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