Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo

Rac1 and Rac2 are thought to have important roles in osteoclasts. Therefore, mice with deletion of both Rac1 and Rac2 in mature osteoclasts (DKO) were generated by crossing Rac1(flox/flox) mice with mice expressing Cre in the cathepsin K locus and then mating these animals with Rac2(−/−) mice. DKO m...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Zhu, Meiling, Sun, Ben-hua, Saar, Katarzyna, Simpson, Christine, Troiano, Nancy, Dallas, Sarah L, Tiede-Lewis, LeAnn M, Nevius, Erin, Pereira, João P, Weinstein, Robert S, Tommasini, Steven M, Insogna, Karl L
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826801/
https://ncbi.nlm.nih.gov/pubmed/26496249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2733
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