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Rac deletion in osteoclasts causes severe osteopetrosis

Cdc42 mediates bone resorption principally by stimulating osteoclastogenesis. Whether its sister GTPase, Rac, meaningfully impacts upon the osteoclast and, if so, by what means, is unclear. We find that whereas deletion of Rac1 or Rac2 alone has no effect, variable reduction of Rac1 in osteoclastic...

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Detalhes bibliográficos
Main Authors: Croke, Monica, Ross, F. Patrick, Korhonen, Matti, Williams, David A., Zou, Wei, Teitelbaum, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225269/
https://ncbi.nlm.nih.gov/pubmed/22114304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.086280
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