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Continuous Elevation of PTH Increases the Number of Osteoblasts via Both Osteoclast-Dependent and -Independent Mechanisms

Sustained parathyroid hormone (PTH) elevation stimulates bone remodeling (ie, both resorption and formation). The former results from increased RANKL synthesis, but the cause of the latter has not been established. Current hypotheses include release of osteoblastogenic factors from osteoclasts or fr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jilka, Robert L, O'Brien, Charles A, Bartell, Shoshana M, Weinstein, Robert S, Manolagas, Stavros C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Subscription Services, Inc., A Wiley Company 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179285/
https://ncbi.nlm.nih.gov/pubmed/20533302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.145
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