ΔF508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis

Deletion of phenylalanine 508 of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the major cause of Cystic Fibrosis (CF), one of the most common inherited childhood diseases. The mutated CFTR anion channel is not fully glycosylated and shows minimal activity in bronchial epithelial...

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Veröffentlicht in:Nature
Hauptverfasser: Pankow, Sandra, Bamberger, Casimir, Calzolari, Diego, Martínez-Bartolomé, Salvador, Lavallée-Adam, Mathieu, Balch, William E., Yates, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826614/
https://ncbi.nlm.nih.gov/pubmed/26618866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15729
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