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A post-translational modification code for CFTR maturation is altered in cystic fibrosis
The multistep process regulating the maturation of membrane proteins in the endoplasmic reticulum (ER) and the secretory pathway is disrupted in many protein misfolding disorders. Mutations in the ion channel CFTR that impair its folding and subsequent localization to the plasma membrane cause cysti...
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| 出版年: | Sci Signal |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6464640/ https://ncbi.nlm.nih.gov/pubmed/30600261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan7984 |
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