Dclk1 defines quiescent pancreatic progenitors that promote injury-induced regeneration and tumorigenesis

The existence of adult pancreatic progenitor cells has been debated. While some favor the concept of facultative progenitors involved in homeostasis and repair, neither a location nor markers for such cells have been defined. Using genetic lineage tracing, we show that Doublecortin like kinase-1 (Dc...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Westphalen, C. Benedikt, Takemoto, Yoshihiro, Tanaka, Takayuki, Macchini, Marina, Jiang, Zhengyu, Renz, Bernhard W., Chen, Xiaowei, Ormanns, Steffen, Nagar, Karan, Tailor, Yagnesh, May, Randal, Cho, Youngjin, Asfaha, Samuel, Worthley, Daniel L., Hayakawa, Yoku, Urbanska, Aleksandra M., Quante, Michael, Reichert, Maximilian, Broyde, Joshua, Subramaniam, Prem S., Remotti, Helen, Su, Gloria H., Rustgi, Anil K., Friedman, Richard A., Honig, Barry, Califano, Andrea, Houchen, Courtney W., Olive, Kenneth P., Wang, Timothy C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826481/
https://ncbi.nlm.nih.gov/pubmed/27058937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.03.016
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