A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2

In humans, cytochrome P450 1A2 is the major enzyme metabolizing environmental arylamines or heterocyclic amines into carcinogens. Since evidence shows that planar triangle-shaped molecules are capable of selectively inhibiting P450 1A2, 16 triangular flavone, and coumarin derivatives were designed a...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Liu, Jiawang, Pham, Peter T., Skripnikova, Elena V., Zheng, Shilong, Lovings, La’nese J., Wang, Yuji, Goyal, Navneet, Bellow, Sydni M., Mensah, Lydia M., Chatters, Amari J., Bratton, Melyssa R., Wiese, Thomas E., Zhao, Ming, Wang, Guangdi, Foroozesh, Maryam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826332/
https://ncbi.nlm.nih.gov/pubmed/26222195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00494
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