A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2

In humans, cytochrome P450 1A2 is the major enzyme metabolizing environmental arylamines or heterocyclic amines into carcinogens. Since evidence shows that planar triangle-shaped molecules are capable of selectively inhibiting P450 1A2, 16 triangular flavone, and coumarin derivatives were designed a...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Liu, Jiawang, Pham, Peter T., Skripnikova, Elena V., Zheng, Shilong, Lovings, La’nese J., Wang, Yuji, Goyal, Navneet, Bellow, Sydni M., Mensah, Lydia M., Chatters, Amari J., Bratton, Melyssa R., Wiese, Thomas E., Zhao, Ming, Wang, Guangdi, Foroozesh, Maryam
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826332/
https://ncbi.nlm.nih.gov/pubmed/26222195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00494
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