A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2

In humans, cytochrome P450 1A2 is the major enzyme metabolizing environmental arylamines or heterocyclic amines into carcinogens. Since evidence shows that planar triangle-shaped molecules are capable of selectively inhibiting P450 1A2, 16 triangular flavone, and coumarin derivatives were designed a...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Liu, Jiawang, Pham, Peter T., Skripnikova, Elena V., Zheng, Shilong, Lovings, La’nese J., Wang, Yuji, Goyal, Navneet, Bellow, Sydni M., Mensah, Lydia M., Chatters, Amari J., Bratton, Melyssa R., Wiese, Thomas E., Zhao, Ming, Wang, Guangdi, Foroozesh, Maryam
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826332/
https://ncbi.nlm.nih.gov/pubmed/26222195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00494
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