DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy

Aneuploidy, the unbalanced number of chromosomes in a cell, is considered a prevalent form of genetic instability and is largely acknowledged as a condition implicated in tumorigenesis. Epigenetic alterations like DNA hypomethylation have been correlated with cancer initiation/progression. Furthermo...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Costa, Giuseppe, Barra, Viviana, Lentini, Laura, Cilluffo, Danilo, Di Leonardo, Aldo
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper: Chromosome
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826165/
https://ncbi.nlm.nih.gov/pubmed/26771138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6897
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items