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RAS-MAPK in ALK targeted therapy resistance

The clinical success of ALK targeted therapy is limited by resistance. To identify rational co-targeting strategies to enhance clinical outcomes, we explored the molecular basis of ALK oncogene dependence in ALK gene rearrangement positive (ALK+) lung adenocarcinoma. We discovered that the RAS-RAF-M...

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Publicat a:Cell Cycle
Autors principals: Hrustanovic, Gorjan, Bivona, Trever G
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825705/
https://ncbi.nlm.nih.gov/pubmed/26654768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1096103
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