A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR

BACKGROUND: Aquaporin 4 (AQP4) is considered a putative autoantigen in patients with Neuromyelitis optica (NMO), an autoinflammatory disorder of the central nervous system (CNS). HLA haplotype analyses of patients with NMO suggest a positive association with HLA-DRB1* 03:01. We previously showed tha...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Arellano, Benjamine, Hussain, Rehana, Miller-Little, William A., Herndon, Emily, Lambracht-Washington, Doris, Eagar, Todd N., Lewis, Robert, Healey, Don, Vernino, Steven, Greenberg, Benjamin M., Stüve, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824350/
https://ncbi.nlm.nih.gov/pubmed/27054574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152720
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