Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy

PKCβII controls the pathologic features of diabetic nephropathy, including glomerular mesangial cell hypertrophy. PKCβII contains the COOH-terminal hydrophobic motif site Ser-660. Whether this hydrophobic motif phosphorylation contributes to high glucose-induced mesangial cell hypertrophy has not be...

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Publicado en:Am J Physiol Cell Physiol
Main Authors: Das, Falguni, Ghosh-Choudhury, Nandini, Mariappan, Meenalakshmi M., Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824156/
https://ncbi.nlm.nih.gov/pubmed/26739493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00266.2015
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