A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy

Loss of ‘Survival of Motor Neurons’ (SMN) leads to spinal muscular atrophy (SMA), a disease characterized by degeneration of spinal cord alpha motor neurons, resulting in muscle weakness, paralysis and death during early childhood. SMN is required for assembly of the core splicing machinery, and spl...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sanchez, Gabriel, Bondy-Chorney, Emma, Laframboise, Janik, Paris, Geneviève, Didillon, Andréanne, Jasmin, Bernard J., Côté, Jocelyn
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824080/
https://ncbi.nlm.nih.gov/pubmed/26656492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1334
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